TWEAK/TNFSF12 Products

Description

CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia. ITEM-4 antibody reacts with both mouse and human Fn14. It is useful for flow cytometric analysis.

Bioinformatics

Entrez	21944 Mouse 8742 Human
Uniprot	AAC51923 Human AAH19047 Human AAH71837 Human AAH71837.1 Human NP_003800 Human NP_057723 Human O43508 Human
Product By Gene ID	8742
Alternate Names	APO3 ligand APO3LMGC20669 DR3LGTWEAKAPO3/DR3 ligand MGC129581 TNF-related weak inducer of apoptosis tumor necrosis factor (ligand) superfamily, member 12 tumor necrosis factor ligand superfamily member 12

Research Areas for TWEAK/TNFSF12

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Apoptosis
Cancer
Tumor Suppressors