Species: Hu, Ca, Pm, Pm
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
FUNCTION: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.; ENZYME REGULATION: Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization. Phosphatidylinositol 4,5-biphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2). SUBUNIT: Homomultimer. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed with a high expression in intestine and prostate. In brain, it is both expressed in whole cerebral arteries and isolated vascular smooth muscle cells.
Bioinformatics
Entrez |
Rat Human Mouse |
Uniprot |
Human Human Rat |
Product By Gene ID |
54795 |
Alternate Names |
- Calcium-activated non-selective cation channel 1
- FLJ20041
- hTRPM4
- Long transient receptor potential channel 4
- LTrpC4
- LTRPC4
- LTrpC-4
- Melastatin-4
- melastatin-4
- PFHB1B
- transient receptor potential cation channel subfamily M member 4
- transient receptor potential cation channel, subfamily M, member 4
- TRPM4B
|