TRIM5 gamma Products

Description

TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region (1). TRIM5 has five alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). While a function has not yet been assigned to TRIM5gamma, it is known that expression of TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys enable resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. Furthermore, the TRIM5delta isoform appears to serve as a scaffold for the assembly of endogenous BTBD1 and BTBD2 proteins and also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner (4).

Bioinformatics

Uniprot	NP_149083 Human
Product By Gene ID	85363
Alternate Names	EC 6.3.2 EC 6.3.2.- RING finger protein 88 RNF88tripartite motif protein TRIM TRIM5alpha tripartite motif containing 5 tripartite motif protein TRIM5 tripartite motif-containing 5 tripartite motif-containing protein 5

Research Areas for TRIM5 gamma

Find related products by research area and learn more about each of the different research areas below.

Immunology
Lipid and Metabolism
Virology, Bacteria and Parasites
Zinc Finger