TRAM/TICAM2 Products

Description

TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (5). Expression of TIRP appears to be essential for TLR4 signalling (6).

Bioinformatics

Entrez	353376 Human
Uniprot	AAO74498 Human AAP81748 Human NM_021649 Human NP_067681 Human NP_067681.1 Human Q86XR7 Human
Product By Gene ID	353376
Alternate Names	MGC129876 MGC129877 Putative NF-kappa-B-activating protein 502 TICAM-2TIR domain-containing adapter molecule 2 TIRAP3 TIRPcytoplasmic adaptor toll/interleukin-1 receptor (TIR) domain-containing adapter protein Toll/interleukin-1 receptor domain-containing protein toll-like receptor adaptor molecule 2 Toll-like receptor adaptor protein 3 TRAMNF-kappa-B-activating protein 502 TRIF-related adapter molecule TRIF-related adaptor molecule