TRAIP Products

Description

The TNF receptor-associated factor (TRAF) family is a group of cytoplasmic adapter proteins that link a wide variety of cell surface receptors including the TNF and IL-1 receptor (TRNFR and IL-1R) superfamily to diverse signaling cascades involved in differentiation, proliferation, activation and apoptosis. TRIP (TRAF-interacting protein) was identified in 1997 as a component of receptor-TRAF signaling complexes (Lee, 1997). TRIP (also known as TRAIP) has been shown to associate with TRNFR2 or CD30 signaling complexes through its interaction with TRAF proteins and inhibit TRAF2-mediated NF-kB activation (Lee, 1997; Regamey et al, 2003). The recruitment of different TRAFs and TRAF associated proteins like TRIP to receptor complexes can help regulate and provide specificity to the intracellular signals triggered by the cell surface receptors.

Bioinformatics

Entrez	10293 Human
Uniprot	NM_005879 Human NP_005870 Human NP_005870.2 Human
Product By Gene ID	10293
Alternate Names	RNF206TRIPRING finger protein 206 TRAF interacting protein TRAF-interacting protein

Research Areas for TRAIP

Find related products by research area and learn more about each of the different research areas below.

Zinc Finger