TOP2A Products

Description

Topo II Alpha encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Bioinformatics

Entrez	21973 Mouse 360243 Rat 7153 Human
Uniprot	NP_001058 Human NP_001058.2 Human P11388 Human
Product By Gene ID	7153
Alternate Names	DNA topoisomerase (ATP-hydrolyzing) DNA topoisomerase 2-alpha DNA topoisomerase II, 170 kD DNA topoisomerase II, alpha isozyme EC 5.99.1.3 TOP2DNA gyrase topoisomerase (DNA) II alpha (170kD) topoisomerase (DNA) II alpha 170kDa TP2A

Research Areas for TOP2A

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Core ESC-Like Genes
DNA Repair
Phospho-Specific
Stem Cell Markers