Species: Hu
Applications: WB
Host: Goat Polyclonal
Species: Hu
Applications: WB, ICC/IF, IHC
Host: Mouse Polyclonal
Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
TOB1 encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells. [provided by RefSeq]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
10140 |
| Alternate Names |
- APRO6
- MGC104792
- PIG49
- protein Tob1
- TOBMGC34446
- Transducer of erbB-2 1
- transducer of ERBB2, 1
- TROB
- TROB1
|
Research Areas for TOB1
Find related products by research area and learn more about each of the different research areas below.
Cell Cycle and Replication
