Thymopoietin/LAP2 Products

Description

Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A-type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eukaryotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, and MANI, three isoforms of lamina-associated polypeptide 1 (LAP 1), and several isoforms of LAP 2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP 2 beta and the nucleoplasmic protein LAP 2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. While LAP 2 beta binds to B-type lamins at the nuclear periphery and was suggested to regulate nuclear lamina growth , LAP 2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent/salt-resistant nucleoskeletal structure.

Bioinformatics

Entrez	21917 Mouse 25359 Rat 7112 Human
Uniprot	NM_001032283 Human NP_001027454 Human NP_003267 Human P42166 Human P42167-2 Human
Product By Gene ID	7112
Alternate Names	CMD1T lamina-associated polypeptide 2 LAP2PRO0868 LEM domain containing 4 LEMD4 MGC61508 Thymopoietin isoform alpha thymopoietin Thymopoietin, isoforms beta/gamma Thymopoietin-related peptide isoform alpha Thymopoietin-related peptide isoforms beta/gamma TP alpha TP beta/gamma TP TPRP isoform alpha TPRP isoforms beta/gamma

Research Areas for Thymopoietin/LAP2

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
DNA replication, Transcription, Translation and Splicing