Thymidine Kinase 1 Products

Description

Thymidine kinase (TK) belongs to a group of enzymes such as dihydrofolate reductase, thymidylate synthase, and DNA polymerase that are involved in DNA synthesis and precursor production. Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells due to multiple regulatory mechanisms that ensure expression of these enzymes exclusively in replicating cells. TK is responsible for catalyzing the phosphorylation of thymidine, which functions as a part of the pyrimidine salvage pathway involved in DNA synthesis. The activities of enzymes such as TK are essential for the activation of several chemotherapeutically important nucleoside analogues that are administered as prodrugs.

Bioinformatics

Entrez	7083 Human
Uniprot	AAH07872.1 Human AAH07986 Human AAH07986.1 Human NP_003249 Human P04183 Human
Product By Gene ID	7083
Alternate Names	EC 2.7.1.21 thymidine kinase 1 soluble isoform thymidine kinase 1, soluble thymidine kinase, cytosolic thymidine kinase-1 TK2

Research Areas for Thymidine Kinase 1

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
DNA replication, Transcription, Translation and Splicing
Stem Cell Markers