TAF10 Products

Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs.

Bioinformatics

Entrez	6881 Human
Uniprot	AAH12088 Human NP_006275 Human NP_006275.1 Human
Product By Gene ID	6881
Alternate Names	30kDa STAF28 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor TAF2ATAFII-30 TAF2Htranscription initiation factor TFIID 30 kD subunit TAFII30TAF(II)30 TATA box binding protein (TBP)-associated factor, RNA polymerase II, H, 30kD Transcription initiation factor TFIID 30 kDa subunit transcription initiation factor TFIID subunit 10