SYNE1 Products

Description

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus.These proteins are called Nesprin l and 2 for nuclear envelope spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM domain-containing sequence essential for perinuclear localization. Nesprin l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as "dystrophins of the nucleus" to maintain nuclear organization and structural integrity. There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called Nesprin l and 2 for nuclear envelope spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as "dystrophins of the nucleus" to maintain nuclear organization and structural integrity.

Bioinformatics

Entrez	23345 Human
Uniprot	NP_892006 Human
Product By Gene ID	23345
Alternate Names	ARCA1 C6orf98 CPG2 dJ45H2.2 EC 4.2.1.49 EC 4.3.1.3 EDMD4 enaptin Enaptin KIAA0796chromosome 6 open reading frame 98 KIAA1262FLJ41140 KIAA17568B Myne-1 MYNE1DKFZp781J13156 Myocyte nuclear envelope protein 1 nesprin 1 nesprin-1 Nuclear envelope spectrin repeat protein 1 SCAR8FLJ30878 spectrin repeat containing, nuclear envelope 1 Synaptic nuclear envelope protein 1 synaptic nuclei expressed gene 1 Syne-1 SYNE-1B