STAT5A Products

Description

Stat5 is part of a 7 protein family known as signal transducer and activator of transcription (STAT) which contributes to signal transduction by cytokine, hormone and growth factor (1). Signal transducer and activator of transcription 5 (Stat5) functions both in signal transduction and activation of transcription. It has been found that cytoplasmic Stat5 is translocated to the nucleus in response to phosphorylation. Stat5 225; tyrosine phosphorylation is activated predominantly by IL2 but also by IL-3, IL-5, IL-7, IL-9, IL-15, G-CSF andGM-CSF(2). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity. NCoA-1/SRC-1 acts as a coactivator for both the alpha- and beta-isoforms of Stat5 (3).

Bioinformatics

Entrez	20850 Mouse 24918 Rat 6776 Human
Uniprot	AAH27036 Human NM_003152 Human NP_003143 Human NP_003143.2 Human P42229 Human P42230 Mouse
Product By Gene ID	6776
Alternate Names	MGF signal transducer and activator of transcription 5A STAT5

Research Areas for STAT5A

Find related products by research area and learn more about each of the different research areas below.

Cancer
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators

Related STAT5A Blog Posts

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Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...    Read more.

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