STAG2 Products

Description

SA2 is a component of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which, sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. The subunit interacts directly with RAD21 in cohesin complex. Cohesin complexes are composed of a heterodimer between a SMC1 protein (SMC1L1 or SMC1L2) and SMC3, which are attached via their hinge domain, and RAD21 links them at their heads, and one STAG protein (STAG1, STAG2 or STAG3). In cohesin complexes, STAG2 is mutually exclusive with STAG1 and STAG3.

Bioinformatics

Entrez	10735 Human 20843 Mouse 313304 Rat
Uniprot	NP_001036214.1 Human NP_006594 Human NP_006594.3 Human Q8N3U4 Human
Product By Gene ID	10735
Alternate Names	bA517O1.1 cohesin subunit SA-2 DKFZp686P168 SA-2 SA2FLJ25871 SCC3 homolog 2 stromal antigen 2DKFZp781H1753

Research Areas for STAG2

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DNA Repair