SSX4 Products

Description

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.

Bioinformatics

Entrez	6759 Human
Uniprot	NM_005636 Human NP_005627 Human NP_005627.1 Human NP_783856 Human
Product By Gene ID	6759
Alternate Names	Cancer/testis antigen 5.4 CT5.4SSX4B MGC119056 MGC12411 protein SSX4 SSX4A synovial sarcoma, X breakpoint 4

Research Areas for SSX4

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Cancer