Src Products

Description

Src is a protein tyrosine kinase known to regulate cellular adhesion. Composed of three major domains; SH2, SH3 and a kinase catalytic domain, Src can be switched from an inactive to an active state though control of its phosphorylation state or through protein-protein interaction. Phosphorylation of Y529 by Csk and Chk inactivates Src, while dephosphorylation of Y529 will modify its conformation to an open active state (1-3). Mutation of Y529 leads to Scr overactivity. Several cancers including colon and breast cancer have been associated with an increase of Src activity (4).

Bioinformatics

Entrez	20779 Mouse 6714 Human 83805 Rat 931 Human
Uniprot	AAH11566 Human NM_005417 Human NP_005408 Human NP_005408.1 Human NP_938033 Human P12931 Human
Product By Gene ID	6714
Alternate Names	c-src EC 2.7.10 EC 2.7.10.2 pp60c-src Rous sarcoma tyrosine kinase pp60c-src tyrosine-protein kinase SRC-1 v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)

Research Areas for Src

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction
Transcription Factors and Regulators
Tyrosine Kinases

Related Src Blog Posts

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