SPG3A Products

Description

SPG3A is encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.

Bioinformatics

Entrez	51062 Human
Uniprot	NP_056999 Human
Product By Gene ID	51062
Alternate Names	AD-FSP atlastin GTPase 1 atlastin1 atlastin-1 Brain-specific GTP-binding protein EC 3.6.5.- FSP1 GBP3 GBP-3 GTP-binding protein 3 Guanine nucleotide-binding protein 3 guanylate-binding protein 3 Spastic paraplegia 3 protein A spastic paraplegia 3A (autosomal dominant) SPG3 SPG3AhGBP3