Spectrin alpha 1 Products

Description

Spectrin is a major constituent of the erythrocyte skeleton accounting for 25% of the total membrane protein and 75% of the cytoskeletal mass. It is associated with the cytoplasmic surface of the membrane by attachment to ankyrin, a peripheral membrane protein. The membrane skeleton influences several cellular properties such as cell shape, restriction of mobility of the integral membrane protein exposed at the cell surface and transmembrane movement of phospholipids and cholesterol. On SDS PAGE gels erythrocyte spectrin appears as two bands referred to as alpha (240 kDa) and beta (220 kDa). While the simplest form of spectrin in solution is an alpha-beta heterodimer, spectrin can undergo self-association in various conditions to form a tetramer of alpha2-beta2. In recent years a large number of spectrin-like molecules have been found in non-erythroid cells. These proteins are known by such different names as fodrin, CBP I, calspectin and TW 260/240.

Bioinformatics

Entrez	6708 Human
Uniprot	P02549 Human P11277 Human
Product By Gene ID	6708
Alternate Names	alpha-I spectrin EL2 erythrocyte HS3 spectrin, alpha, erythrocytic 1 (elliptocytosis 2)

Research Areas for Spectrin alpha 1

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Cytoskeleton Markers