SNRPN Products

Description

The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.

Bioinformatics

Entrez	6638 Human
Uniprot	AAH03180 Human AAH03180.1 Human AAH24777 Human NM_003097 Human NM_022805 Human NP_073717 Human NP_073718 Human NP_073719 Human P63162 Human
Product By Gene ID	6638
Alternate Names	DKFZp686C0927 DKFZp686M12165 DKFZp761I1912 DKFZp762N022 FLJ39265 HCERN3FLJ33569 MGC29886 Prader-Willi syndrome chromosome region PWCR RT-LI Sm protein D Sm protein N small nuclear ribonucleoprotein polypeptide N small nuclear ribonucleoprotein-associated protein N SM-D Sm-D SmN Sm-N sm-N SMNFLJ36996 SNRNP-N snRNP-N SNURF-SNRPN tissue-specific splicing protein Tissue-specific-splicing protein

Research Areas for SNRPN

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Diabetes Research