SMN2 Products

Description

Gemin 1 (SMN) is the central component of a large oligomeric complex (SMN complex), including Gemins 2-7, that is necessary and sufficient for the in vivo assembly of Sm proteins onto the small nuclear (sn)RNAs that mediate pre-mRNA splicing. The SMN complex is found in the cytoplasm and nucleus. Within the nucleus, this protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). Spinal muscular atrophy, a motor neuron disorder, results from reduced levels or a mutation in the Gemin 1 protein.

Bioinformatics

Entrez	6607 Human
Uniprot	AAH00908 Human ABM85660.1 Human NP_059107 Human NP_075013.1 Human NP_075014 Human NP_075015 Human
Product By Gene ID	6607
Alternate Names	BCD541 C-BCD541 Component of gems 1 FLJ76644 gemin 1 Gemin-1 gemin-1 MGC20996 MGC5208 SMN SMNCSMN1 SMNT survival motor neuron protein survival of motor neuron 2, centromeric

Research Areas for SMN2

Find related products by research area and learn more about each of the different research areas below.

Neuroscience