SMAD1/5/8/9 Products

Description

SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily (1). SMADs can be divided into receptor-regulated SMADs (R-SMADs: SMAD1, SMAD2, SMAD5, SMAD8 and SMAD9), common-mediator SMAD (co-SMAD: SMAD4), and inhibitory SMADs (I-SMADs: SMAD6 and SMAD7). SMAD1, SMAD5, SMAD8 and SMAD9 have high degrees of homology and antibodies are available that recognize sequences common to all of them. SMAD8 and SMAD9 are typically used as alternate names for one another in the literature. Human SMAD1 is a 465 amino acid protein; GenBank Accession No. AAP36050.1. Human SMAD2 is a 467 amino acid protein; GenBank Accession No. AAC51918.1 Human SMAD3 is a 425 amino acid protein; GenBank Accession No. NP_005893.1 Human SMAD4 is a 552 amino acid protein GenBank Accession No. NP_005350.1. Human SMAD5 is a 465 amino acid protein; GenBank Accession No. AAC50791.1. Human SMAD6 is a 496 amino acid protein; GenBank Accession No. AAH12986.1 Human SMAD7 is a 426 amino acid protein; GenBank Accession No. AAB81354.1 Mouse SMAD8 is a 430 amino acid protein; GenBank Accession No. AAN85445.1 Human SMAD9 is a 430 amino acid protein; GenBank Accession No. NP_005896.1

Bioinformatics

Entrez	17125 Mouse 25671 Rat 4086 Human
Uniprot	Q15797 Human
Product By Gene ID	4086
Alternate Names	BSP1 BSP-1 hSMAD1 JV4-1SMAD, mothers against DPP homolog 1 (Drosophila) MAD homolog 1 MADH1JV41 MADR1MAD, mothers against decapentaplegic homolog 1 (Drosophila) Mad-related protein 1 mothers against decapentaplegic homolog 1 mothers against decapentaplegic homolog 1 Mothers against DPP homolog 1 SMAD family member 1SMAD 1 SMAD, mothers against DPP homolog 1 Smad1 TGF-beta signaling protein 1 transforming growth factor-beta signaling protein 1

Research Areas for SMAD1/5/8/9

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Cancer
Diabetes Research