Sirtuin 2/SIRT2 Products

Description

Silent information regulator 2 (Sir2) family of enzymes has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging. O-acetyl-ADP-ribose causes a delay/block in oocyte maturation and results in a delay/block in embryo cell division in blastomeres. It has been demonstrated that the production of O-acetyl-ADP-ribose is evolutionarily conserved among Sir2-like enzymes from yeast, Drosophila, and human. Also, endogenous yeast Sir2 complex from telomeres was shown to generate O-acetyl-ADP-ribose (1). SIRT2 is a predominantly cytoplasmic protein that colocalizes with microtubules. SIRT2 deacetylates lysine-40 of alpha-tubulin both in vitro and in vivo. Knockdown of SIRT2 via siRNA results in tubulin hyperacetylation. SIRT2 colocalizes and interacts in vivo with HDAC6, another tubulin deacetylase (2). Cytoskeleton-related protein, SIRT2 is down-regulated in gliomas, and data suggests that ectopic expression of SIRT2 in glioma cell lines led to the perturbation of the microtubule network (3).

Bioinformatics

Entrez	22933 Human
Uniprot	AAH03012 Human NM_012237 Human NP_036369 Human NP_036369.2 Human NP_085096 Human NP_085096.1 Human Q8IXJ6 Human
Product By Gene ID	22933
Alternate Names	EC 3.5.1 EC 3.5.1.- FLJ35621 FLJ37491 S.cerevisiae, homolog) 2 sirtuin 2 sirtuin type 2

Research Areas for Sirtuin 2/SIRT2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Chromatin Research
DNA Repair
Epigenetics
Histone Deacetylases
Neuronal Cell Markers
Transcription Factors and Regulators