SGK3 Products

Description

SGKL/SGK3, also known as CISK for cytokine-independent survival kinase, is a SGK type protein kinase. The protein contains a lipid-binding phox homology (PX) domain, which is required for targeting SGKL/SGK3 protein to the endosomal compartment. SGKL/SGK3 functions downstream of the phosphoinositide 3-kinase (PI3K) cascade and has been implicated in cell survival. The protein has been shown to be phosphorylated and activated by 3-phosphoinositide-dependent protein kinase 1 (PDK1), and to a lesser extent insulin-like growth factor-1, in vitro. Activated SGKL/SGK3 has been shown to phosphorylate glycogen synthase kinase 3 beta (GSK-3beta) in vitro. SGKL/SGK3 expression has been documented in many human tissues but was found to be most abundant in lung. ESTs have been isolated from human tissue libraries, including normal liver, breast and thyroid and cancerous spleen, ear and pancreas.

Bioinformatics

Entrez	100533105 Human 171498 Rat 23678 Human 27219 Mouse
Uniprot	AAH15326 Human NM_001033578 Human NM_013257 Human NP_733827 Human Q96BR1 Human
Product By Gene ID	23678
Alternate Names	CISK DKFZp781N0293 EC 2.7.11 EC 2.7.11.1 serine/threonine-protein kinase Sgk3 serum/glucocorticoid regulated kinase 3 serum/glucocorticoid regulated kinase family, member 3 serum/glucocorticoid regulated kinase-like Serum/glucocorticoid-regulated kinase 3 Serum/glucocorticoid-regulated kinase-like SGK2 SGKLcytokine-independent survival kinase

Research Areas for SGK3

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GPCR
Protein Kinase

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