SAE2 Products

Description

Covalent attachment of one protein to another is one of the more prominent posttranslational modifications in respect to size and ubiquity. Ubiquitin is the most familiar of the protein modifiers and its activation and transfer to target proteins has been studied extensively. Recently, a new group of ubiquitin-like proteins has been receiving a lot of attention. SUMO, or Sentrin, is one of the most intriguing. SUMO has been implicated in the stabilization of target proteins and/or their localization to sub-cellular complexes. The conjugation of SUMO-1, SUMO-2 and SUMO-3 onto target proteins requires the concerted action of the specific E1-activating enzyme SAE1/SAE2, the E2-conjugating enzyme Ubc9, and an E3-like SUMO ligase.

Bioinformatics

Entrez	10054 Human
Uniprot	NM_005499 Human NP_005490 Human NP_005490.1 Human Q9UBT2 Human
Product By Gene ID	10054
Alternate Names	Anthracycline-associated resistance ARX ARX EC 6.3.2 EC 6.3.2.- FLJ13058 HRIHFB2115 SAE2SUMO-1 activating enzyme subunit 2 SUMO1 activating enzyme subunit 2 SUMO-activating enzyme subunit 2 UBA2, ubiquitin-activating enzyme E1 homolog Ubiquitin-like 1-activating enzyme E1B ubiquitin-like modifier activating enzyme 2 UBLE1B

Research Areas for SAE2

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Stem Cell Markers