S1P1/EDG-1 Products

Description

EBP 50 [ERM (ezrin-radixin-moesin) binding phosphoprotein of 50 kDa] is a PDZ containing protein that is involved in the linkage of integral membrane proteins to the cytoskeleton. EBP50 contains two tandem PDZ domains followed by a carboxy-terminal sequence that binds to members of the ERM family of membrane-cytoskeleton adaptors. The PDZ domains within EBP50 bind to the carboxy termini of such target proteins as beta2 adrenergic receptor, platelet-derived growth factor receptor (PDGFR), and the cystic fibrosis conductance regulator (CFTR). The PDZ domains are also believed to be involved in the oligomerization of EBP 50 to form multiprotein complexes which helps to facilitate the formation of functional signalling complexes. EBP 50 has been shown to link integral membrane proteins to the cytoskeleton by binding to members of the ERM family of proteins, which bind to F-actin. Through these interactions, EBP 50 is implicated in the localization of interactive groups of proteins into subcellular domains and in the regulation of activity of those interacting proteins. Immunohistochemical studies have shown that EBP 50 is found exclusively at the apical membranes of epithelial cells.

Bioinformatics

Entrez	13609 Mouse 1901 Human 29733 Rat
Uniprot	AAH18650 Human NP_001391 Human NP_001391.2 Human O08530 Mouse P21453 Human
Product By Gene ID	1901
Alternate Names	CD363 antigen CD363 CHEDG1 D1S3362 EDG-1 EDG1edg-1 Endothelial differentiation G-protein coupled receptor 1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 FLJ58121 S1P receptor 1 S1P receptor Edg-1 s1p1 S1P1ECGF1 sphingosine 1-phosphate receptor 1 sphingosine 1-phosphate receptor EDG1 Sphingosine 1-phosphate receptor Edg-1 sphingosine-1-phosphate receptor 1

Research Areas for S1P1/EDG-1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cytoskeleton Markers
GPCR
Lipid and Metabolism
Neuroscience
Signal Transduction