Ryanodine Receptor 1 Products

Description

The Ryanodine Receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR 1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR 2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

Bioinformatics

Entrez	114207 Rat 20190 Mouse 6261 Human 686059 Rat
Uniprot	P21817 Human
Product By Gene ID	6261
Alternate Names	CCO central core disease of muscle MHS MHS1 PPP1R137 protein phosphatase 1, regulatory subunit 137 ryanodine receptor 1 (skeletal) ryanodine receptor 1 ryanodine receptor type1 RYDR RYR RyR1 RYR-1 sarcoplasmic reticulum calcium release channel Skeletal muscle calcium release channel skeletal muscle ryanodine receptor Skeletal muscle-type ryanodine receptor SKRR type 1-like ryanodine receptor

Research Areas for Ryanodine Receptor 1

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Neuroscience