RPL10 Products

Description

The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, while Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. A distant member of the MAP kinase family, designated c-Jun NH2-terminal kinase (JNK1) functions to regulate c-Jun by phosphorylation at the amino terminal serine regulatory sites, Ser 63 and Ser 73). QM has been described as a transcription factor that can function to bind DNA directly or alternatively can interact with c-Jun to inhibit transactivation of AP-1 promoter driven reporter vectors by Jun-Jun homodimers. QM is highly conserved throughout eukaryotic evolution and is apparently a member of a multi-gene family.

Bioinformatics

Entrez	110954 Mouse 6134 Human
Uniprot	AAH03358 Human NM_006013 Human NP_006004 Human P27635 Human
Product By Gene ID	6134
Alternate Names	60S ribosomal protein L10 DXS648EFLJ27072 DXS648FLJ23544 Laminin receptor homolog NOV Protein QM QMDKFZp686J1851 ribosomal protein L10 Tumor suppressor QM Wilms tumor-related protein