Rffl Products

Description

RFFL, also known as Rififylin, RING finger and FYVE-like domain-containing protein 1, FYVE-RING finger protein, Sakura, Fring, Caspases-8 and -10-associated RING finger protein 2, CARP-2, Caspase regulator CARP2, RING finger protein 189 and RING finger protein 34-like, is a novel modulator of NF-kB activation. RFFL possesses E3 ubiquitin protein ligase activity and has been shown to regulate the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. RFFL also possesses anti-apoptotic activity and may bind phosphatidylinositol phosphates. RFFL is a membrane bound cytoplasmic protein that is expressed ubiquitously. RFFL can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes and is rapidly degraded after stimulation with TNFSF10, and probably by caspases. Multiple transcript variants have been detected for this protein.

Bioinformatics

Entrez	117584 Human
Uniprot	AAH28424.1 Human NP_001017368 Human Q8WZ73 Human
Product By Gene ID	117584
Alternate Names	CARP-2 Caspase regulator CARP2 Caspases-8 and -10-associated RING finger protein 2 E3 ubiquitin-protein ligase rififylin EC 6.3.2 EC 6.3.2.- fring Fring FYVE-RING finger protein Sakura RIFIFYLIN rififylin ring finger and FYVE-like domain containing 1 RING finger and FYVE-like domain-containing protein 1 RING finger protein 189 RING finger protein 34-like RNF189CARP2 RNF34LFRING