Rab11A Products

Description

Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in coordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There are over 40 Rab proteins in mammals. Rab11a and Rab11b are known markers for protein trafficking, sorting, and recycling in the endosomal pathway. The Rab11 proteins are enriched in recycling endosomes and the trans-Golgi network, where they regulate membrane recycling back to the plasma membrane. Rab11a is ubiquitously expressed, while Rab11b is expressed mainly in the heart and brain.

Bioinformatics

Entrez	53869 Mouse 81830 Rat 8766 Human
Uniprot	AAH13348 Human AAH13348.1 Human NM_004663 Human NP_004654 Human NP_004654.1 Human P62491 Human
Product By Gene ID	8766
Alternate Names	MGC1490 RAB 11A, member oncogene family RAB11 rab-11 Rab-11 RAB11A, member RAS oncogene family YL8ras-related protein Rab-11A

Research Areas for Rab11A

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Cancer
Tumor Suppressors