PTBP1 Products

Description

PTBP1 belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Bioinformatics

Entrez	19205 Mouse 29497 Rat 5725 Human
Uniprot	AAH13694 Human NM_002819 Human NM_031991 Human NP_002810 Human NP_002810.1 Human P26599 Human
Product By Gene ID	5725
Alternate Names	Heterogeneous nuclear ribonucleoprotein I heterogeneous nuclear ribonucleoprotein polypeptide I hnRNP I HNRNPI HNRNP-I HNRPI MGC10830 MGC8461 polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoproteinI) polypyrimidine tract binding protein 1 polypyrimidine tract-binding protein 1 pPTB PTB-1 PTB2 PTB3 PTB4 PTB57 kDa RNA-binding protein PPTB-1 PTB-T RNA-binding protein