Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt, Bv, Ca, Eq, Ma-Op, Pm
Applications: WB
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
Presenilin (PS1/PS2) complexes are responsible for the intramembrane gamma-secretase cleavage of the beta-amyloid precursor protein. Presenilin enhancer 2 (PEN2) is an essential cofactor involved in physically interacting with PS1 and is necessary for gamma-secretase activity. Endogenous PEN2 preferentially interacts with PS1 holoprotein. Down-regulation of PEN2 expression abolishes the endoproteolysis of PS1 and overexpression promotes the production of PS1 fragments.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
55851 |
| Alternate Names |
- gamma-secretase subunit PEN-2
- MSTP064
- PEN-2
- PEN2hematopoietic stem/progenitor cells protein MDS033
- presenilin enhancer 2 homolog (C. elegans)
- Presenilin enhancer protein 2
|
