POLR3E Products

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway

Bioinformatics

Entrez	55718 Human
Uniprot	AAH00285 Human NP_060589 Human Q9NVU0 Human
Product By Gene ID	55718
Alternate Names	DNA-directed RNA polymerase III 80 kDa polypeptide DNA-directed RNA polymerase III subunit RPC5 FLJ10509 KIAA1452 polymerase (RNA) III (DNA directed) polypeptide E (80kD) RNA polymerase III 80 kDa subunit RPC5 RNA polymerase III subunit C5 RPC5 SIN