PIGL Products

Description

PIGL, also referred to as N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, is approximately 29 kDa and 252 amino acids in length. PIGL localizes to the endoplasmic reticulum and is an important player the synthesis of GPI anchors as it catalyzes the second step in the reaction. Current research on PIGL is being performed relating to several diseases and disorders including congenital heart disease, babesiosis, ear anomalies syndrome, ichthyosiform dermatosis, malaria and sleeping sickness. PIGL has also been shown to have interactions with PIGA, PIGC, PIGH, DPM2, and GPLD1 in pathways such as GPI anchor biosynthesis and metabolic pathways.

Bioinformatics

Entrez	9487 Human
Uniprot	NP_004269 Human NP_004269.1 Human Q9Y2B2 Human
Product By Gene ID	9487
Alternate Names	EC 3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase phosphatidylinositol glycan anchor biosynthesis, class L phosphatidylinositol glycan, class L Phosphatidylinositol-glycan biosynthesis class L protein PIG-L