PHOX2A Products

Description

PHOX2A is encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.

Bioinformatics

Entrez	116648 Rat 11859 Mouse 401 Human
Uniprot	NP_005160 Human NP_005160.2 Human
Product By Gene ID	401
Alternate Names	aristaless (Drosophila) homeobox, aristaless homeobox (Drosophila), fibrosis ofextraocular muscles, congenital, 2, autosomal recessive aristaless homeobox homolog Aristaless homeobox protein homolog arix homeodomain protein ARIX1 homeodomain protein ARIXNCAM2 CFEOM2MGC52227 paired mesoderm homeobox protein 2A paired-like homeobox 2apaired-like (aristaless) homeobox 2a PMX2AFEOM2

Research Areas for PHOX2A

Find related products by research area and learn more about each of the different research areas below.

Growth and Development
Neuronal Cell Markers
Neuroscience