PDE4B Products

Description

PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Enzymes of the cAMP-dependent phosphodiesterase type 4 (PDE4) family are important in hydrolyzing cAMP produced by G-protein coupled receptor (GPCR) stimulated adenylyl cyclases. Four genes (PDE4A, B, C and D) make up the PDE4 family. cAMP-dependent phosphodiesterase type B (PDE4B) family consists of four known splice variants, PDE4B1, B2, B3 and a novel 66 kDa PDE4B4 protein. One or more subtype variants of PDE4B are ubiquitously present in all mammalian cells. In CNS, all four PDE4B subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Some PDE4B variants are also substrate for PKA-dependent phosphorylation. Peripheral tissues exhibit differential expression of PDE4B1, B2 and B4 variants; the PDE4B4 (66kDa protein) is the major PDE4B variant expressed in lungs, testis and heart. In testis PDE4B enzymes are expressed in somatic cells (Sertoli and Leydig cells) while PDE4A is localized in germ cells.

Bioinformatics

Uniprot	NM_001037339 Human NM_002600 Human NP_001032418 Human NP_002591 Human Q07343 Human Q5TEK5 Human
Product By Gene ID	5142
Alternate Names	cAMP-specific (phosphodiesterase E4 dunce homolog cAMP-specific 3'-5'-cyclic phosphodiesterase 4B cAMP-specific phosphodiesterase-4 B isoform DKFZp686F2182 Drosophila) dunce-like phosphodiesterase E4 EC 3.1.4 EC 3.1.4.17 MGC126529 PDE32 PDEIVB phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homologphosphodiesterase E4) phosphodiesterase 4B, cAMP-specific (dunce phosphodiesterase 4B, cAMP-specific phosphodiesterase E4 dunce homolog

Research Areas for PDE4B

Find related products by research area and learn more about each of the different research areas below.

Cancer
Signal Transduction