PDCD4 Products

Description

Programmed cell death 4 (Pdcd4) is a novel tumor suppressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphorylation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1 responsive promoters by c-Jun.

Bioinformatics

Uniprot	AAH26104 Human AAH26104.1 Human AAH31049 Human B5ME91 Human NP_055271 Human NP_055271.2 Human NP_663314 Human Q53EL6 Human
Product By Gene ID	27250
Alternate Names	H731nuclear antigen H731 MGC33046 MGC33047 Neoplastic transformation inhibitor protein Nuclear antigen H731-like programmed cell death 4 (neoplastic transformation inhibitor) programmed cell death protein 4 Protein 197/15a

Research Areas for PDCD4

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific