Species: Hu, Mu, Rt
Applications: WB, Flow, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Mu
Applications: WB, IHC
Host: Mouse Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
The normal progression of cells through the cell cycle is under the control of the cyclin dependent protein kinases Cdk4 and Cdk6 which are subject to inhibition by the mitotic inhibitory protein, p16. An isolated member of the p16 family has been designated p15. p15 expression is upregulated approximately 30-fold in TGFbeta-treated human keratinocytes, suggesting that p15 may act as an effector of TGFbeta-mediated cell cycle arrest. The gene encoding p15 has been mapped to chromosome 9p21 at a position adjacent to the p16 gene at a site of frequent chromosomal abnormality in human tumors. It has been suggested that p15 may function as an effector of TGFbeta-mediated cell cycle arrest through inhibition of Cdk4 and Cdk6 kinases.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
1030 |
| Alternate Names |
- CDK4I
- cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
- cyclin-dependent kinases 4 and 6 binding protein
- INK4BCDK4B inhibitor
- MTS-2
- MTS2CDK inhibitory protein
- Multiple tumor suppressor 2
- p14_CDK inhibitor
- p14_INK4B
- p14-INK4b
- p15 CDK inhibitor
- p15_INK4B
- P15cyclin-dependent kinase 4 inhibitor B
- p15INK4B
- p15INK4b
- p15-INK4b
- TP15
|
Research Areas for p15INK4b/CDKN2B
Find related products by research area and learn more about each of the different research areas below.
Cell Cycle and Replication
![Western Blot p15INK4b/CDKN2B Antibody (651308) [Unconjugated]](http://images.novusbio.com/fullsize2/p15INK4b_MAB6798_Western_Blot_10931.jpg)
![Immunocytochemistry p15INK4b/CDKN2B Antibody (651308) [Unconjugated]](http://images.novusbio.com/fullsize2/p15INK4b_MAB6798_Immunocytochemistry__Immunofluorescence_19647.jpg)
