p130 Products

Description

Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain." Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.

Bioinformatics

Uniprot	CAA52671 Human NM_005611 Human NP_005602 Human NP_005602.3 Human Q08999 Human
Product By Gene ID	5934
Alternate Names	FLJ26459 p130 P130 pRb2 PRB2 RB2 Rb2 RBR-2 retinoblastoma-like 2 (p130) retinoblastoma-like protein 2,130 kDa retinoblastoma-associated protein Retinoblastoma-related protein 2

Research Areas for p130

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Phospho-Specific
Tumor Suppressors