OSBPL2 Products

Description

OSBPL2 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.

Bioinformatics

Uniprot	NM_144498 Human NP_055650 Human NP_055650.1 Human NP_653081.1 Human
Product By Gene ID	9885
Alternate Names	KIAA0772FLJ20223 ORP-2MGC4307 ORP2MGC8342 OSBP-related protein 2 oxysterol binding protein-like 2 oxysterol-binding protein-like 2 oxysterol-binding protein-related protein 2

Research Areas for OSBPL2

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Lipid and Metabolism