Nuf2 Products

Description

Nuf2, also known as Kinetochore protein Nuf2, is a 54 kDa 464 amino acid protein, and it is involved in chromosome segregation, specifically as it relates to spindle checkpoint activity with the kinetochore-associated NDC80 complex. This protein is necessary for kinetochore stability and organization of microtubule binding sites on the outer plate, forming interactions with NDC80/HEC-1-CDCA1, SPBC24-SPBC25, Bub1, EXOC1, as well as AURKB/Aurora-B and CENPE in the mitotic prometaphase, DNA replication, and Cell Cycle pathways. Current research is being performed on this proteins involvement in gastric, lung, and breast cancers, in addition to essential hypertension, schizophrenia, and duodenogastric reflux.

Bioinformatics

Uniprot	AAH08489 Human NM_031423 Human NP_663735 Human
Product By Gene ID	83540
Alternate Names	cancer/testis antigen 106 CDCA1hsNuf2 cell division cycle associated 1 Cell division cycle-associated protein 1 CT106 hNuf2 kinetochore protein Nuf2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) NUF2RhNuf2R

Research Areas for Nuf2

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication