Notch-2 Products

Description

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membraneFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Bioinformatics

Uniprot	NP_077719 Human NP_077719.2 Human Q04721 Human
Product By Gene ID	4853
Alternate Names	AGS2 hN2 neurogenic locus notch homolog protein 2 Notch (Drosophila) homolog 2 notch 2Notch homolog 2 (Drosophila) Notch homolog 2

Research Areas for Notch-2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Golgi Apparatus Markers
Growth and Development
Neuronal Cell Markers
Signal Transduction
Stem Cell Signaling Pathway