Musculin Products

Description

Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins, known to play an important role in the regulation of muscle cell development, includes MyoD, myogenin and musculin (also designated MyoR). Members of this group of transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. MyoD-E or musculin-E heterodimers bind avidly to consensus E box motifs, which are functionally important elements in the promoter regions of many musclespecific terminal differentiation genes. MyoD complexes potently induce transcriptional activation, while musculin complexes bind adjacent to MyoD DNA-binding regions to represses MyoD activity, which then results in the delayed expression of muscle-specific genes. Musculin is highly expressed in undifferentiated and proliferating myoblasts in culture, and its expression is down regulated during myogenesis and at the onset of terminal differentiation

Bioinformatics

Uniprot	AAC15071.1 Human NP_005089 Human O60682 Human
Product By Gene ID	9242
Alternate Names	ABF1 ABF-1activated B-cell factor 1, homolog of mouse musculin Activated B-cell factor 1 BHLHA22 bHLHa22activated B-cell factor-1 Class A basic helix-loop-helix protein 22 musculin (activated B-cell factor-1) musculin MYOR