mGluR7 Products

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez	108073 Mouse 14807 Mouse 2899 Human 2917 Human 298521 Rat 81672 Rat
Uniprot	NM_000844 Human NP_000835 Human NP_000835.1 Human P35400 Rat Q13003 Human Q14831 Human
Product By Gene ID	2917
Alternate Names	FLJ40498 glutamate receptor, metabotropic 7 metabotropic glutamate receptor 7 mGlu7 MGLU7 mGluR7 mGluR7 MGLUR7GPRC1GGLUR7

Research Areas for mGluR7

Find related products by research area and learn more about each of the different research areas below.

GPCR
Metabotropic Glutamate Receptors
Neuronal Cell Markers
Neuroscience
Neurotransmission
Phospho-Specific
Vision