MEK5 Products

Description

Mitogen-acitvated protein kinase kinase 5 (MKK5) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1-2). The MAPK cascade plays an important role in signaling defense responses. Of the MKK family members, MKK5 exhibits the closest homology to MEK1 and MEK2, with 46% amino acid identity in the catalytic domain (3) MKK has been show to activate extracellular-signal-regulated protein kinase 5 (ERK5). Also, activated ERK5 phosphorylates mitogen- MKK5 extensively at Ser129, Ser137, Ser142 and Ser149, which are located within the region in MKK5 that is thought to interact with ERK5 (3). There have also been findings to that the MEK5 (MKK5)/ERK5 (BMK) pathway may play a role in prostate cancer (5).

Bioinformatics

Entrez	23938 Mouse 29568 Rat 5607 Human
Uniprot	AAH08838 Human NP_002748 Human NP_660143 Human NP_660143.1 Human Q13163 Human Q62862 Rat
Product By Gene ID	5607
Alternate Names	HsT17454 MAP kinase kinase 5 MAP kinase kinase MEK5b MAPK/ERK kinase 5 MAPKK 5 MAPKK5EC 2.7.12.2 MEK5MEK 5 mitogen-activated protein kinase kinase 5 MKK5 PRKMK5dual specificity mitogen-activated protein kinase kinase 5

Research Areas for MEK5

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Phospho-Specific
Protein Kinase