MED6 Products

Description

MED6 also known as Mediator of RNA polymerase II transcription subunit 6, is a 246 amino acid protein that is 28 kDa; as a component of the Mediator complex, a co-activator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes, functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery, by direct interactions with regulatory proteins the mediator is recruited to promoters and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Disease research is currently being performed with relation to MED6 and spondylolysis, renal carcinoma, carcinoma, renal cell carcinoma, cholesterol, and neuronitis. This protein has also been shown to have interactions with over 70 proteins including SMAD2, SMAD1, CDK8, MED15, and MED25 in developmental biology, transcriptional regulation of white adipocyte differentiation, generic transcription pathway, gene expression, and transcription ligand-dependent transcription of retinoid-target genes pathways.

Bioinformatics

Entrez	10001 Human
Uniprot	AAH04106 Human NM_005466 Human NP_005457.2 Human
Product By Gene ID	10001
Alternate Names	Activator-recruited cofactor 33 kDa component ARC33 mediator complex subunit 6hMed6 mediator of RNA polymerase II transcription subunit 6 mediator of RNA polymerase II transcription, subunit 6 homolog (S. cerevisiae) mediator of RNA polymerase II transcription, subunit 6 homolog NY-REN-28 Renal carcinoma antigen NY-REN-28