Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt, Gt
Applications: ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Mu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB, ELISA, MA, AP, NULL
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
MDR1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). MDR1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. (provided by RefSeq)
Bioinformatics
| Entrez |
Mouse
Mouse
Rat
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
5243 |
| Alternate Names |
- ABC20
- ATP-binding cassette sub-family B member 1
- ATP-binding cassette, sub-family B (MDR/TAP), member 1
- CD243 antigen
- CD243
- CLCS
- colchicin sensitivity
- doxorubicin resistance
- EC 3.6.3
- EC 3.6.3.44
- GP170
- IBD13
- MDR1MGC163296
- multidrug resistance protein 1
- P-glycoprotein 1
- P-gp
- PGY1P-GP
|
