Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF
Host: Rabbit Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE, Enzyme Activity
Species: Ec
Applications: PAGE, Enzyme Activity
Species: Hu
Applications: AC
Description
This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. [provided by RefSeq, Feb 2016]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
4190 |
| Alternate Names |
- aromatic alpha-keto acid reductase
- cytoplasmic
- Cytosolic malate dehydrogenase
- DEE88
- Diiodophenylpyruvate reductase
- EC 1.1.1.37
- EC 1.1.1.96
- EIEE88
- epididymis secretory protein Li 32
- HEL-S-32
- HEL-S-32
- KAR
- malate dehydrogenase 1, NAD (soluble)
- Malate dehydrogenase, cytoplasmic
- malate dehydrogenase, cytoplasmic; malate dehydrogenase, peroxisomal
- MDH1
- MDHA
- MDH-s
- MGC:1375
- MOR2
- soluble malate dehydrogenase
|
