Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Host: Mouse Polyclonal
Species: Hu
Applications: WB
Host: Mouse Polyclonal
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Description
The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
Bioinformatics
| Entrez |
Human
Mouse
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
225689 |
| Alternate Names |
- EC 2.7.11
- ERK-7
- ERK7MAPK 15
- ERK-8
- ERK8EC 2.7.11.24
- extracellular regulated kinase 8 delta
- extracellular signal regulated kinase 8
- Extracellular signal-regulated kinase 7
- Extracellular signal-regulated kinase 8
- MAP kinase 15
- mitogen-activated protein kinase 15
|
