MAP3K8/Tpl2/COT Products

Description

The role of mitogen-activated protein kinases (MAPKs) in cell signaling pathways is well established. The rat gene Tpl-2, for tumor progression locus 2, and the human and mouse homologues c-Cot, for cancer osaka thyroid oncogene, encode a proto-oncogene serine/threonine protein kinase that was shown to play a role in the functional activation of the MAP kinase pathway. Overexpression of Cot induces MAP kinase activation in COS-1 and NIH/3T3 cells. Cot-mediated activation of MAP kinase is inhibited by both Ras N17, a dominant negative mutant of c-H-Ras, and Raf-1s621A, a dominant negative mutant of Raf-1, suggesting that Cot functions upstream of Ras and Raf-1.Other studies have shown that a kinase-negative, dominant negative mutant of Cot partially blocks Ras or Raf-1-induced MAP kinase activation, arguing that Cot functions downstream of Ras and Raf-1. To explain these contrasting findings, it has been suggested that Cot, Ras and Raf-1 may form a multimeric complex that phosphorylates MEK-1. Cot has also been shown to be implicated in T lymphocyte activation.

Bioinformatics

Entrez	116596 Rat 1326 Human 26410 Mouse
Uniprot	AAI13567 Human NM_005204 Human NP_005195 Human P41279 Human
Product By Gene ID	1326
Alternate Names	Cancer Osaka thyroid oncogene c-COT cot (cancer Osaka thyroid) oncogene COTMEKK8 EC 2.7.11.25 ESTF ESTFLJ10486 Ewing sarcoma transformant mitogen-activated protein kinase kinase kinase 8 Proto-oncogene c-Cot proto-oncogene serine/threoine protein kinase Serine/threonine-protein kinase cot TPL2 Tpl-2 TPL-2 Tumor progression locus 2 tumor progression locus-2

Research Areas for MAP3K8/Tpl2/COT

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Phospho-Specific
Protein Kinase