Kv1.6 Products

Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homologs. This protein is a member of the potassium channel, voltage-gated, shaker-related subfamily. Kv1.6 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. Kv1.6 is a homologue of the Drosophila gene Shaker, which is involved in reduced sleep and life expectancy.

Bioinformatics

Entrez	16494 Mouse 3742 Human 64358 Rat
Uniprot	P17658 Human
Product By Gene ID	3742
Alternate Names	FLJ25134 HBK2 human brain potassium channel-2 Kv1.6 KV1.6 potassium voltage-gated channel subfamily A member 6 potassium voltage-gated channel, shaker-related subfamily, member 6 Voltage-gated potassium channel HBK2 voltage-gated potassium channel protein Kv1.6 Voltage-gated potassium channel subunit Kv1.6