Kv1.2 Products

Description

KCNA2 (Potassium voltage-gated channel subfamily A member 2) mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which K(+) ions may pass in accordance with their electrochemical gradient. KCNA2 binds PDZ domains of DLG1, DLG2 and DLG4. The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Bioinformatics

Entrez	16490 Mouse 25468 Rat 3737 Human
Uniprot	NM_004974 Human NP_000153 Human NP_004965.1 Human P63142 Rat
Product By Gene ID	3737
Alternate Names	EC 3.6.1.27 EC 6.1.1 HBK5 HK4 HUKIV Kv1.2 KV1.2 MGC50217 MK2 NGK1 potassium channel potassium voltage-gated channel subfamily A member 2 potassium voltage-gated channel, shaker-related subfamily, member 2 RBK2 Voltage-gated K(+) channel HuKIV Voltage-gated potassium channel HBK5 voltage-gated potassium channel protein Kv1.2 Voltage-gated potassium channel subunit Kv1.2

Research Areas for Kv1.2

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism
Neuroscience
Neurotransmission
Potassium Channels